Mississippi

PMHNP Practice Requirements In Mississippi: Scope, Prescribing & Collaboration

Short answer: AANP lists Mississippi as reduced practice, so a PMHNP practices under a formal collaborative agreement with a Mississippi physician in a compatible practice, approved by the Board of Nursing before practice begins at each site (30 Mississippi Administrative Code Part 2840, Rule 1.4). Schedules II through V are allowed with Board approval and a DEA registration, and the Mississippi PMP must be checked for every initial controlled substance prescription (Part 2840, Rule 1.5).

Mississippi PMHNP Rules At A Glance

Topic	Mississippi Rule
Practice authority	Reduced practice. APRNs practice to national certification standards but must work in a collaborative relationship with a Mississippi licensed physician whose practice is compatible, and must be able to communicate reliably with that physician while practicing (Part 2840, Rule 1.4.C).
Physician agreement	A formal collaborative agreement naming each practice site, submitted to the Board before you start, plus an on site QA/QI program. New APRNs also log 1,000 or 2,000 monitored hours with a qualifying provider present (Part 2840, Rules 1.3, 1.4).
Physician limit	No APRN per physician cap appears in the Medical Board’s current rules. The physician must practice in Mississippi 20 hours a week, review 10% or 20 of your charts monthly, and meet you quarterly (Part 2630, Rules 1.2, 1.8).
Controlled substances	Schedules II through V with Board approval, an extra fee, and a DEA registration (Part 2840, Rule 1.5.A, 1.5.C). Benzodiazepines are limited to a one month supply with two refills or 90 days with none (Rule 1.5.D.4).
PDMP	Enroll in the Mississippi PMP as a condition of certification, then check it before every initial controlled substance prescription and at each visit where an opioid or benzodiazepine is prescribed, and document it (Part 2840, Rules 1.4.F, 1.5.D.3).
Regulator	Mississippi Board of Nursing (msbn.ms.gov) certifies APRNs and approves collaborative agreements through the Nurse Gateway under Miss. Code 73-15-20; the State Board of Medical Licensure regulates the collaborating physician (Part 2630).

Updated October 5, 2026

Practice Authority

Mississippi Practice-Authority Category (Reduced Practice)

AANP currently classifies Mississippi as a reduced practice state on its State Practice Environment map. A PMHNP there practices in many respects on their own. It isn’t full independence, though, because state law requires a collaborative agreement or other physician involvement for at least one element of practice, such as prescribing.

For the national comparison, the AANP State Practice Environment map and AANP’s practice information by state show where Mississippi sits. The binding rules come from the Mississippi Board of Nursing.

Collaboration

Is A Collaborative Or Supervisory Agreement Required?

Mississippi generally requires an NP to keep a collaborative or supervisory arrangement with a physician for at least part of practice, usually written up as a collaborative practice agreement. State rule sets what that agreement must contain, which parts of practice it covers (prescribing, for example), how it’s documented and how often it’s reviewed.

Our guide to PMHNP collaborative practice agreements covers what these agreements usually contain, and the PMHNP scope of practice by state overview puts Mississippi side by side with every other state.

Prescriptive Authority

Prescriptive Authority And Controlled Substances

Meet the requirements in Mississippi and you can be granted prescriptive authority, which can reach controlled substances once the conditions are met. In Mississippi, though, some or all prescribing may be tied to the required collaborative or supervisory arrangement. To prescribe those, you’ll need your own federal DEA registration, and some substances carry additional federal or state conditions. Federal registration goes through the U.S. Drug Enforcement Administration. On the state side, state law and the rules of the Mississippi Board of Nursing set the scope, any limits and the documentation.

Next Step

Credentialing Is A Separate Track

Your Mississippi license and practice authority don’t enroll you with a single payer. Getting paid is a separate track, with its own payer rules, Medicaid program and enrollment timelines, and we cover it on the Mississippi credentialing and payer enrollment page. The PMHNP credentialing guide has the national picture.

Opening your own practice? Get licensure, collaboration and enrollment in the right order with our guide on how to start a PMHNP practice and the 90-day launch checklist. Money usually comes up next, and the answers are in what PMHNP credentialing costs and what it costs to start a PMHNP practice.

Already credentialed and moving to your own Tax ID? Payer Transition moves five commercial payer contracts you already hold for $2,250 per provider. Starting from zero, First Practice Launch sets up the payers, EHR, portals and billing together for $6,000, or four monthly payments of $1,500.

FAQ

Frequently Asked Questions

Can A PMHNP Practice Independently In Mississippi?

No. Every APRN must practice in a collaborative relationship with a Mississippi physician in a compatible practice, with the formal agreement filed and approved before practice begins (Part 2840, Rule 1.4). New APRNs also complete 1,000 or 2,000 monitored practice hours with a qualifying provider physically on the premises, depending on prior RN experience (Rule 1.3). Full practice authority bills have been filed but had not passed as of October 2026.

Do I Need A Collaborating Physician In Mississippi?

Yes, at least one for each practice site. The physician must hold an unrestricted Mississippi license, have a compatible practice, and be reachable while you work (Part 2840, Rules 1.1.D, 1.4.C). On the physician’s side, the Medical Board requires monthly review of 10% or 20 of your charts and a documented face to face meeting each quarter (Part 2630, Rule 1.8). A psychiatrist isn’t mandatory; the Board posts a PMHNP template for collaborating with a non-psychiatrist.

Can A PMHNP Prescribe Adderall In Mississippi?

Yes. APRNs may prescribe Schedules II through V after Board approval of controlled substance authority and DEA registration (Part 2840, Rule 1.5.A). Before an initial controlled substance prescription you must check the Mississippi PMP, using at least six months of history on a new patient, and document it in the record (Rule 1.5.D.3). Schedule II drugs can’t be prescribed for weight loss (Rule 1.5.E).

This is general information, not legal advice. It applies the general nurse practitioner rules in Mississippi to PMHNPs, and those rules aren’t the same for every role. Rules change, so check with the Mississippi Board of Nursing and the AANP State Practice Environment map before you act on it. Last reviewed: September 26, 2026.

Keep Reading

Related PMHNP Resources

Scope By State

Compare requirements across states on our PMHNP scope of practice by state overview.

Start A Practice

See the full sequence in how to start a PMHNP practice.

Credentialing

Learn what we handle on our PMHNP credentialing page, or visit the PMHNP services hub.